• Phadia Product Catalogue

Miscellaneous

Anti-IgA | Sperm Antibodies   

  

 Anti-IgA

NEW!

Products

Article No.

No. of tests
EliA Anti-IgA 14-5535-01 2 x 12

 

Antigen

Purified human IgA

Promotion material

Flyer on EliA Anti-IgA (pdf)

Disease association and antibody prevalence

  • 40% of patients with selective IgA deficiency
  • 10 to 25% of patients with Common Variable Immunodeficiency (CVID)
Selective IgA deficiency is most common in celiac disease, while CVID is the most common symptomatic primary immunodeficiency (prevalence ~ 0.004%) characterized by low serum levels of IgG, IgA and variably IgM.   

Prevent anaphylactoid reactions

Immunoglobulin G (IgG) replacement therapy represents an effective prophylaxis for infections in CVID patients. However, in any given IgG product, traces of IgA (0.05 to 6.0 mg/dl depending on the product) can be found. Therefore, patients with anti-IgA antibodies are at risk to develop an anaphylactoid reaction to these IgG formulations, especially upon intravenous andministration. The frequency of transufsion reactions is approximately 1 in 30,000 in the general population, while it is as high as up to 1 in 30 in IgA deficiency. 

When is the measurement recommended?

  1. Mandatory:
    Patients who have IgA deficiency and are destined for blood transfusion or IgG replacement therapy.
  2. Recommended:
    Celiac disease patients who are IgA deficient in order to assess a future risk for blood transfusions.
  3. Useful:
    Any IgA deficient patient in order to assess a future risk for blood transfusions.

Antibody isotype

IgG

References

  • Thon (2010) Screening of IgG anti-IgA antibodies in hypogammaglobulinemic subjects to prevent anaphylactoid reactions. CLI online: www.cli-online.com/index.php?id=2909
  • Yuan S and Goldfinger D (2008) A readily available assay for anti-immunoglobulin A: is this what we have been waiting for? Transfusion 48, 2048-2050
  • Kumar V et al (2002) Celiac disease and immunoglobulin A deficiency: How effective are the serological methods of diagnosis? Clin Diag Lab Immunol 9, 1295-1300
  • Horn J et al (2006) Anti-IgA antibodies in Common Variable Immunodeficiency (CVID): Diagnostic workup and therapeutic strategy. Clin Immunol 122, 156–162
  • Lilic D and Sewell WAC (2008) IgA deficiency: what we should - or should not – be doing. J. Clin. Pathol. 54, 337-338
  • Brown R et al (2008) An evaluation of the DiaMed assays for immunoglobulin A antibodies (anti-IgA) and IgA deficiency. Transfusion 48, 2057-2059  

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Sperm Antibodies

Products

Article No.

No. of tests
Varelisa Sperm Antibodies 1 44 96 96

 

Antigen

Human sperm surface proteins purified 

 

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  Sperm Antibodies